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This paper studies linear regression models for high dimensional multi-response data with a hybrid quantum computing algorithm. We propose an intuitively appealing estimation method based on identifying the linearly independent columns in the coefficient matrix. Our method relaxes the low rank constraint in the existing literature and allows the rank to diverge with dimensions. The linearly independent columns are selected by a novel non-oracular quantum search (NQS) algorithm which is significantly faster than classical search methods implemented on electronic computers. Besides, NQS achieves a near optimal computational complexity as existing quantum search algorithms but does not require any oracle information of the solution state. We prove the proposed estimation procedure enjoys desirable theoretical properties. Intensive numerical experiments are also conducted to demonstrate the finite sample performance of the proposed method, and a comparison is made with some popular competitors. The results show that our method outperforms all of the alternative methods under various circumstances. 

Combining statistical parametric maps (SPM) from individual subjects is the goal in some types of group‐level analyses of functional magnetic resonance imaging data. Brain maps are usually combined using a simple average across subjects, making them susceptible to subjects with outlying values. Furthermore,ttests are prone to false positives and false negatives when outlying values are observed. We propose a regularized unsupervised aggregation method for SPMs to find an optimal weight for aggregation, which aids in detecting and mitigating the effect of outlying subjects. We also present a bootstrap‐based weightedttest using the optimal weights to construct an activation map robust to outlying subjects. We validate the performance of the proposed aggregation method and test using simulated and real data examples. Results show that the regularized aggregation approach can effectively detect outlying subjects, lower their weights, and produce robust SPMs.